OCTOBER SPECIAL - Breast Cancer package
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Does Cannabis Cure Breast Cancer? – The Facts About Cannabinoids
Researchers find cannabis oil fights Breast Cancer. Worldwide, breast cancer comprises 10.4% of all cancer incidence among women, making it the second most common type of non-skin cancer (after lung cancer) and the fifth most common cause of cancer death.
In 2004, breast cancer caused 519,000 deaths worldwide (7% of cancer deaths; almost 1% of all deaths).
Cannabidiolic acid (CBDA) is an inhibitor of MDA-MB-231 breast cancer cell migration (stops them spreading) and cannabidiol (CBD), is a major non-psychotropic constituent of cannabis, that has been reported to possess anti-proliferative effect (stops growth or their ability to multiply ) on cancer cells.
Scientists at California Pacific Medical Center who have been researching marijuana compounds for over 20 years confirm that cannabidiol, or CBD, has the ability to switch off the DNA that causes breast and other types of cancers to metastasize.
CBD is the second-most abundant cannabinoid within marijuana, but does not cause the psychotropic high of THC .Although some highly successful treatments have been developed, certain breast tumors are resistant to conventional therapies and a considerable number of them relapse.
Experimental evidence accumulated during the last decade supports the fact that cannabinoids and their derivatives, possess anticancer properties.
These compounds exert anti-proliferative, pro-apoptotic, anti-migratory and anti-invasive actions in a wide spectrum of cancer cells in culture. Moreover, tumor growth, angiogenesis and metastasis are hampered by cannabinoids. Read more.
Dr. Pierre Desprez completed his Ph.D. at the University of Lyon in France, and worked as a postdoctoral fellow in the laboratories of Drs. Judith Campisi and Mina Bissell at the Lawrence Berkeley National Laboratory on mammary gland development, breast cancer and cellular senescence in particular. Desprez reports:
“We started by researching breast cancer, but now we’ve found that cannabidiol works with many kinds of aggressive cancers; brain, prostate, any kind in which these high levels of ID-1 are present.”.
Results of the current investigation revealed that CBDA inhibits migration of the highly invasive MDA-MB-231 human breast cancer cells (through a mechanism involving inhibition of cAMP-dependent protein kinase A, coupled with an activation of the small GTPase).
In the United States alone, breast cancer affects hundreds of thousands of women and many men every year. Some non-invasive forms of the disease are relatively treatable, but many types are far more aggressive.
Triple-Negative breast cancer
Researchers have discovered that cannabidiol (CBD) found in the cannabis plant has the ability to switch off the gene responsible for metastasis in an aggressive form of breast cancer called triple-negative.
Most breast cancers are facilitated by hormone epidermal growth factor receptor 2 (HER-2), estrogen receptors, and/or progesterone receptors.
Although there are many types of breast cancer, they are usually grouped into four categories, depending on how they show up on diagnostic tests:
Estrogen receptor positive (ER+) or progesterone receptor positive (PR+) are relatively common and can occur in two in three cases of breast cancer, particularly in older women, and these have receptors sensitive to one or both of these hormones.
Since Triple-Negative Breast Cancer cells do not express these receptors, there are less ways to fight them. This form, which affects 15% of patients, doesn’t have three hormone receptors that the most successful therapies target.
Scientists discovered that the CBD compound had turned off the over-expression of ID-1, stopping them from travelling to distant tissues.
Cells from this cancer have high levels of ID-1. When scientists exposed cells from this cancer to cannabidiol they found the cells returned to a healthy normal state.
Other potentially treatable cancers that respond well to cannabis oil extract are forms of leukaemia, lung, ovarian and brain cancers, which also have high levels of ID-1. Research into other forms of cancer indicate similar results.
A recent study indicated that,a proportion of these cells exhibit cannabinoid receptors, making cannabinoids one of the most suitable potential targeted treatments, particularly for Triple-Negative Breast Cancer. A further study reported in Molecular Oncology reported in 2015:
“The anti-tumor role and mechanisms of Cannabidiol (CBD), a non-psychotropic cannabinoid compound, are not well studied especially in triple-negative breast cancer (TNBC). In the present study, we analyzed CBD’s anti-tumorigenic activity against highly aggressive breast cancer cell lines including TNBC subtype. We show here for the first time-that CBD significantly inhibits epidermal growth factor (EGF)-induced proliferation and chemotaxis of breast cancer cells.”
(HER2 or ErbB2) is a protein that is over-copied by certain types of breast cancer. HER2-positive cancers spread more rapidly than other types of cancer. Triple negative breast cancers do not have estrogen or progesterone receptors and don’t show overproduction of HER2.
Triple-negative breast cancers spread aggressively because they don’t respond to hormones or drugs that target HER2, but chemotherapy is an option. These types of breast cancer are ER+ and PR+, and they have too much HER2 production. They can be treated with hormones, HER2 drugs, and chemo.
Research has shown that PR+, HER2-positive, and triple-negative breast cancers can be effectively treated with cannabis. The protocols recommended should have high THC-to-CBD ratios.
Patients with ER+ or triple-positive breast cancer require lower ratios of THC to CBD – a ratio 1:1 to 1:3 is preferable.
Cannabinoid receptors are overexpressed in the tumors of particular cancers, such as those of the breast, liver, lungs, and prostate. Cannabinoids from cannabis bind with these receptors and either switch off the cell’s ability to divide and replicate or simply kill it (apoptosis).
In this manner, full spectrum cannabis oils containing both cannabinoids (CBD and THC) can work in tandem with the body’s endocannabinoid system to induce cancer cell death, inhibit cell growth, or prevent the metastasis (spread) of cancer cells. In addition, unlike chemotherapy treatments, cannabinoids can prevent healthy cell damage.
Full spectrum of cannabinoids to treat breast cancer
Cancers that involve estrogen may actually spread in response to large amounts of THC.
There is also a significant role for THC in the treatment of cancer, studies have suggested that different cannabinoids fight different forms of breast cancer. THC has been shown to induce apoptosis in ErbB2–positive breast cancer cells and inhibits tumor growth in animal models. CBD is known to work at the genetic level, blocking expression of the ID-1 gene to inhibit breast cancer metastasis.
However, the ratios of THC and CBD must be matched to the classification of breast cancer, evidence suggests that with certain kinds of breast cancer, namely those that are estrogen-positive, the tumor will actually grow if too much THC is used.
Results show that the most effective cannabis oils are what is known as 1:1 profile, this means the oil contains equal amounts of both CBD and THC along with lesser amounts of other cannabinoids.
There are few strains of cannabis that will produce this profile as most plants developed for the recreational market today have been bred to contain significant amounts of THC and reduced CBD.
Before considering drastic surgery or aggressive chemotherapy it is worth noting that a new scientific study has confirmed that: most women diagnosed with breast cancer via mammography, never had a cancer problem to begin with.
Almost 93% of early detection has no benefit to the patient whatsoever, according to a new study published in the New England Journal of Medicine.
Study co-author Dr. Gilbert Welch states, “We found that the introduction of screening has been associated with about 1.5 million additional women receiving a diagnosis of early stage breast cancer.”
Dr. Welch’s team discovered, there was virtually no reduction in late-stage breast cancer from these early diagnosis, meaning that many women who were told they had breast cancer after a mammogram were being mislead.
Most women diagnosed agree to start treatment immediately, this consists of injections of expensive and highly toxic chemicals which oncologist prescribe to the very same patients they have incorrectly diagnosed.
Furthermore, The U.S. Preventive Services Task Force recently advised that most women don’t need mammograms as early or often as previously believed.
Stefanie LaRue: Cannabis Advocate & Breast Cancer Survivor
In 2005, Stefanie’discovered a lump in one of her breasts, she was only 30 years old. Initially she was misdiagnosed by three different doctors and was told that she was too young for breast cancer.
Stefanie was treated with prescribed antibiotics, which failed to have any effect, so by the time she was tested and correctly diagnosed, the cancer had spread to her bones.
Doctors diagnosed her with Stage 4 Metastatic Breast Cancer, meaning the cancer had spread beyond the breast to other organs in the body. There is no stage 5. The prognosis she was given predicted one year to live, at most.
With help from her oncologist at UCLA, Stefanie learned to make changes to her diet, use natural supplements and work on personal fitness; all of which are integrative and complimentary treatments alongside chemotherapy.
After six chemotherapy treatments, Stefanie had surgery to remove the cancer which removed all of her breast tissue.
In 2013 Stefanie had a Video-Assisted Thoracoscopic Surgery (VATS) and the results indicated her third re occurrence of cancer. The chemo sensitivity testing concluded there were five lines of chemo treatments that could work on the tumors.
“I did my homework. I researched as much as I could. I watched. I listened. I read. I contacted. I prayed. Most of all, I believed. I weighed my options, which were essentially chemotherapy or cannabis oil, and I decided to take the natural route this time.”
“Cannabis oil killed all of the tumors in my body. My monthly lab and quarterly scan results are proof that the cannabis oil treatment worked.”
Her last scan in December of 2014 showed no signs of cancerous tumors. Her doctor, who had previously been skeptical, now credits these “alternative” treatments as the reason for her speedy recovery.
Florida Woman Treated Breast Cancer with Cannabis
Although the disease quickly began to spread, she refused to seek traditional treatments.
“They thought I was absolutely insane. They’re like it’s not going work, you can’t be doing this, and I was like it’s my body, and this is what I want to do.”
Despite going against doctor’s orders by relying on strictly cannabis oil, she is now cancer free, and doctors are now interested as to how cannabis is keeping the disease at bay. Tammy Levent’s bloodwork tumor markers are still all zero and oncologists are at a loss to explain it.
Breast Cancer Also Occurs in Men
Breast cancer is not gender specific and an early diagnosis helped save Stephen Sala, who opted for conventional treatment without cannabis oil. In August 2016 he found a small lump on the right side of his chest. His doctor scheduled an ultrasound and a mammogram the same day, followed by a needle biopsy a week later. The results showed breast cancer. He was 41.
“I experienced a number of awkward situations. Almost all mammography offices are in women’s health care centers, with no consideration for men. I was given forms that asked me when my last period was and how many children I had given birth to.”
12 Signs of Breast Cancer
Thick mass: A sudden thickening of the breast tissue can be a sign of a serious underlying condition such as lobular or inflammatory breast cancer
Indentation: Some people notice a dip, or dent, in the breast. This can be because the cancer is tethered to the breast tissue and so pulls it inwards
Skin erosion: In rare cases cancer that is growing under the skin can break through and create a wound
Heat or redness: If the breast feels warm to touch or there’s redness one-third of the breast, it can be a sign of inflammatory breast cancer
New fluid: Spontaneous nipple discharge on one side, which may be blood stained, brown or clear, might mean there is something in the breast that is causing irritation
Dimpling: Dimpled skin is a common sign of inflammatory breast cancer
Bump: A localised swelling, bulge or bump on the breast should always be investigated
Growing vein: Changes such as dilated veins can be a sign that cancer is blocking a blood vessel
Retracted nipple: Developing an inverted nipple – i.e. not being born with one – which can’t be drawn out, may suggest a lump behind the nipple is pulling it in.
New shape or size: Any change in shape or size not associated with the menstural cycle should be investigated
Orange peel skin: Skin that has ridges or appears pitted, like the skin of an orange, can be caused by a build up of fluid in the breast
Invisible lump: Even though there are many other symptoms, it’s crucial to always check your breasts for lumps. A cancerous lump often feels hard and immovable like a lemon seed.
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