There are three main types of lung cancer. Knowing which type you have is important because it affects your treatment options and your outlook (prognosis). If you aren’t sure which type of lung cancer you have, ask your doctor so you can get the right information.
2013 - Editorial ~ Cannabis and the Lung: No More Smoking Gun?
2013 - Study ~ Effects of marijuana smoking on the lung.
2013 - News ~ Marijuana habit not linked to lung cancer
2012 - News ~ Can marijuana stop cancer?
2012 - News ~ Is Marijuana the Cancer Cure We’ve Waited For?
2012 - News ~ Study: Smoking Marijuana Not Linked with Lung Damage
2011 - Study ~ Effects of smoking cannabis on lung function.
2008 - Letter ~ Doubts about the role of cannabis in causing lung cancer.
2007 - News - Marijuana May Fight Lung Tumors.
2007 - News ~ Marijuana Cuts Lung Cancer Tumor Growth In Half, Study Shows.
2007 - News ~ Pot's Active Ingredient Halts Lung Cancer Growth, Study Says.
2007 - News ~ Marijuana Helps to Combat Lung Cancer.
2007 - News ~ Cannabis as a possible treatment for lung cancer.
2007 - News ~ Marijuana Beneficial in Fighting Lung Tumors, Study.
2006 - Study - Marijuana Smoking Found Non-Carcinogenic.
2006 - News ~ Study Finds No Link Between Marijuana Use And Lung Cancer.
2006 - News ~ Study Finds No Cancer-Marijuana Connection.
2006 - News ~ Pot Smoking Not Linked to Lung Cancer.
2006 - News ~ Large Study Finds No Link between Marijuana and Lung Cancer.
2005 - Study ~ Cannabis and tobacco smoke are not equally carcinogenic.2005 - News ~ Cannabis Smoke Is Less Likely To Cause Cancer Than Tobacco Smoke.
2000 - Report - Anti-Tumor Effects.
1999 - News ~ So, you thought it was the tar that caused cancer.1994 - News ~ Marijuana Less Harmful to Lungs than Cigarettes.
1975 - Study - Anticancer activity of cannabinoids.
1975 - Study - Antineoplastic activity of cannabinoids.
Little is known about the activity of cannabinoids like THC on epidermal growth factor receptor-overexpressing lung cancers, which are often highly aggressive and resistant to chemotherapy.
In this study, we characterized the effects of THC on the EGF-induced growth and metastasis of human non-small cell lung cancer using the cell lines A549 and SW-1573 as in vitro models.
We found that these cells express the cannabinoid receptors CB(1) and CB(2), known targets for THC action, and that THC inhibited EGF-induced growth, chemotaxis and chemoinvasion. Moreover, signaling studies indicated that THC may act by inhibiting the EGF-induced phosphorylation of ERK1/2, JNK1/2 and AKT.
THC also induced the phosphorylation of focal adhesion kinase at tyrosine 397. Additionally, in in vivo studies in severe combined immunodeficient mice, there was significant inhibition of the subcutaneous tumor growth and lung metastasis of A549 cells in THC-treated animals as compared to vehicle-treated controls. Tumor samples from THC-treated animals revealed antiproliferative and antiangiogenic effects of THC.
Our study suggests that cannabinoids like THC should be explored as novel therapeutic molecules in controlling the growth and metastasis of certain lung cancers.Oncogene advance online publication, 9 July 2007; doi:10.1038/sj.onc.1210641